COLIONE Lamons

Product category: Medicine containing Colistin Sulphate

Indicated for treatment of gastrointestinal tract infections caused by Escherichia coli susceptible to colistin. 

Mechanism of action

Penetration through the bacterial cell membrane, causing changes in its permeability, as a consequence of the interaction with the phospholipid components. These changes alter the osmotic barrier, making the bacteria more sensitive to their chemical environment and allowing their ultimate lysis. 

Spectrum of action

Colistin is a bactericidal antibiotic, especially efrective against gram-negative bacteria, particularly Enterobacteriaceae. Colistin has practically no activity against gram-positive bacteria or fungi. Gram-positive bacteria are naturally resistant to colistin, as well as other gram negative-bacteria like Proteus and Serratia. However, it is rare for enteric gram-negative bacteria to develop resistance, and in cases where it does happen, it is due to a single-step mutation.